Here at EnzBond we believe in cheap and efficient solutions to the synthetic problems. That's why we've developed a platform that can finally solve the key problem of biocatalysis -
efficient enzyme development.

Why we do it

Enzyme Design revolution

The modern scientific revolution has been galvanized by the expansion of computers and algorithms to perform data processing. Enzyme Design has seen a dramatic shift in the last 20 years from an experimental heavy Darwin evolution method of random mutations and screening to a rational computational method using algorithms to delineate the importance of residues in a sequence to the activity. The glass ceiling has been reached through as the success rate of discovery has had a hard time surpassing 10% and the average fold improvement in activity reaching only 5x. Over the last 20 years, the field has compressed the development effort from multiple years and tens of employees to 6 months and 4 employees.
But that is as good as it gets.

EnzBond break through

EnzBond has broken through with its’ proprietary technology and has increased the success rate of discovery to the highest levels seen in the industry and an average fold improvement far surpassing the current methods. These improvements have not been a one-off situation but have replicated across 8 different enzymes classes! No Such breath in engineering has been seen prior.
More importantly, 1 person can now develop 2 new enzymes in as little as four months.

Below we discuss the secret to the EnzBond led Enzyme Revolution

At the core of all EnzBonds technology is an answer to two simple questions:

 

What is catalysis and What causes protein instability

 

Through years of “chalkboard design” and months of R&D, EnzBond was able to refine a theorem for “Catalysis” which has allowed us to accurately predict the turnover of an Enzyme far faster than any platform currently available.

 

Activity is just half the story though.


As we began to investigate 10,000’s of different sequences we needed to determine which ones had gained stability and those that have lost it. EnzBond has developed an Artificial Intelligence platform that can be fed sequences that have 1 mutation all the way up to 200 mutations and still produce thermal shift data with high accuracy.

 


 

The combination of both proprietary platforms has allowed EnzBond to produce enzymes with greater than 7 fold improvement in turn-over in one round and increase the success-rate of discovery* to greater than 60%.